Title : In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.

Pub. Date : 2006 May

PMID : 16611376






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes. Folic Acid tumor protein p53 Homo sapiens
2 The results indicate that p53 expression was downregulated in folate-deficient lymphocytes when compared with the control lymphocytes during the relevant period of S phase accumulation and apoptosis. Folic Acid tumor protein p53 Homo sapiens
3 These results suggest that IL-2 depletion by folate deficiency in lymphocytes reduces the bcl-2 level, thereby triggering deoxynucleoside triphosphate pool imbalance and p53-independent apoptosis. Folic Acid tumor protein p53 Homo sapiens