Title : Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3.

Pub. Date : 2006 Apr

PMID : 16549446






1 Functional Relationships(s)
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1 Furthermore, HMEC cultures were dose dependently growth inhibited by physiological concentrations of 25(OH)D3, suggesting that CYP27B1 converts this precursor cholecalciferol metabolite to 1alpha,25(OH)2D3, the ligand for the vitamin D receptor (VDR). Cholecalciferol cytochrome P450 family 27 subfamily B member 1 Homo sapiens