Title : Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.

Pub. Date : 2006 Apr

PMID : 16539839






11 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
2 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
3 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
4 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
5 AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
6 The aim of this study was to investigate whether chemical interactions can modulate nicotine-induced COX-2 expression in human gingival fibroblasts (HGF). Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
7 Treatment of HGF with nicotine was shown to mediate COX-2 protein expression. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
8 Pretreatment with OTZ decreased nicotine-induced COX-2 protein level by approximately 60 % (P<0.05). Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
9 However, BSO enhanced nicotine-induced COX-2 protein level up to approximately 3-fold (P<0.05). Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
10 Treatment of HGF with PD98059 decreased nicotine-induced COX-2 protein expression. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens
11 CONCLUSION: Nicotine may play a significant role in the pathogenesis of cigarette smoking associated-periodontitis via the activation of COX-2 which is augmented by oxidative stress and mediated by extracellular signal-regulated protein kinase signaling. Nicotine prostaglandin-endoperoxide synthase 2 Homo sapiens