Pub. Date : 2006 Apr
PMID : 16539839
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | AIM: Activation of cyclooxygenase-2 (COX-2) expression by nicotine suggests a potential role for nicotine in the pathogenesis of smoking-associated periodontal disease. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | The aim of this study was to investigate whether chemical interactions can modulate nicotine-induced COX-2 expression in human gingival fibroblasts (HGF). | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 7 | Treatment of HGF with nicotine was shown to mediate COX-2 protein expression. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 8 | Pretreatment with OTZ decreased nicotine-induced COX-2 protein level by approximately 60 % (P<0.05). | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 9 | However, BSO enhanced nicotine-induced COX-2 protein level up to approximately 3-fold (P<0.05). | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 10 | Treatment of HGF with PD98059 decreased nicotine-induced COX-2 protein expression. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 11 | CONCLUSION: Nicotine may play a significant role in the pathogenesis of cigarette smoking associated-periodontitis via the activation of COX-2 which is augmented by oxidative stress and mediated by extracellular signal-regulated protein kinase signaling. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |