Title : Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP.

Pub. Date : 2006 May 15

PMID : 16513268






3 Functional Relationships(s)
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1 Here, we report that Ptprz-deficient mice exhibit impairments in hippocampus-dependent contextual fear memory because of abnormal tyrosine phosphorylation of p190 RhoGAP, a GTPase-activating protein (GAP) for Rho GTPase. Tyrosine Rho GTPase activating protein 35 Mus musculus
2 We found that phosphorylation at Y1105, a major tyrosine phosphorylation site on p190 RhoGAP, is decreased 1h after the conditioning in the hippocampus of wild-type mice, but not of Ptprz-deficient mice. Tyrosine Rho GTPase activating protein 35 Mus musculus
3 Pleiotrophin, a ligand for Ptprz, increased tyrosine phosphorylation of p190 RhoGAP in B103 neuroblastoma cells. Tyrosine Rho GTPase activating protein 35 Mus musculus