Title : The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks.

Pub. Date : 2006 Feb 16

PMID : 16483373






3 Functional Relationships(s)
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1 We demonstrated that one of the novel candidates, 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), a natural ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), triggers the rhythmic expression of endogenous clock genes in NIH3T3 cells. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
2 We demonstrated that one of the novel candidates, 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), a natural ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), triggers the rhythmic expression of endogenous clock genes in NIH3T3 cells. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
3 Furthermore, we showed that 15d-PGJ2 transiently induces Cry1, Cry2, and Roralpha mRNA expressions and that 15d-PGJ2-induced entrainment signaling pathway is PPAR-gamma--and MAPKs (ERK, JNK, p38MAPK)-independent. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus