Title : PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation.

Pub. Date : 2006 May

PMID : 16406609






1 Functional Relationships(s)
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1 Here, we report that two structurally distinct PI3K inhibitors, wortmannin and LY294002, inhibited insulin-induced activation of ERK1/2 but had no effect on EGF-induced activation of ERK1/2 in hepatocellular carcinoma BEL-7402 and SMMC-7721 cells, breast cancer MCF-7 cells, and prostate cancer LNCaP cells. smmc mitogen-activated protein kinase 3 Homo sapiens