Title : Effects of pirenzepine on Dai-kenchu-to-induced elevation of the plasma neuropeptide levels in humans.

Pub. Date : 2006 Jan

PMID : 16394532






2 Functional Relationships(s)
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1 We examined the effects of the selective M(1) muscarinic receptor antagonist pirenzepine on the elevation of Dai-kenchu-to-induced plasma neuropeptide (gastrin, motilin, somatostatin, VIP, CGRP, substance P)-IS levels in human volunteers and the area under the plasma neuropeptide concentration-time curve from 0 to 240 min (AUC(0-->240 min)), which were calculated from the plasma neuropeptide concentration-time curves from each volunteers. Pirenzepine gastrin Homo sapiens
2 Combined treatment with Dai-kenchu-to and pirenzepine increased plasma somatostatin-IS levels and decreased plasma gastrin-IS levels and had no effects on plasma CGRP- and substance P-IS levels and AUC(0-->240 min) compared with administration of Dai-kenchu-to alone. Pirenzepine gastrin Homo sapiens