Title : Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism.

Pub. Date : 2005 Nov

PMID : 16340453






7 Functional Relationships(s)
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1 Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Alcohols proopiomelanocortin Homo sapiens
2 Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Alcohols proopiomelanocortin Homo sapiens
3 METHODS: The response of the pituitary beta-endorphin to a placebo or an alcohol (0.50 g ethanol/kg) drink and to a stress task performed 30 min following ingestion of either the placebo or the alcohol drink was measured in social and heavy drinkers with [high risk (HR)] and without [low risk (LR)] a family history of alcoholism. Alcohols proopiomelanocortin Homo sapiens
4 Thus, alcohol dependence decreased the basal plasma beta-endorphin levels in LR only, as well as the stress induced increase in plasma beta-endorphin levels of participants without, but not of those with, a family history of alcoholism. Alcohols proopiomelanocortin Homo sapiens
5 Thus, alcohol dependence decreased the basal plasma beta-endorphin levels in LR only, as well as the stress induced increase in plasma beta-endorphin levels of participants without, but not of those with, a family history of alcoholism. Alcohols proopiomelanocortin Homo sapiens
6 Alcohol prior to stress attenuated the stress-induced increase in plasma beta-endorphin levels of all four groups of participants. Alcohols proopiomelanocortin Homo sapiens
7 Thus, in HR individuals a dysfunction in the activity of the pituitary beta-endorphin system predates the development of alcoholism, while in LR individuals it develops following alcohol dependence. Alcohols proopiomelanocortin Homo sapiens