Title : Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II.

Pub. Date : 2006 Apr 1

PMID : 16339402






6 Functional Relationships(s)
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1 Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II. Dermatan Sulfate serpin family D member 1 Homo sapiens
2 Dermatan sulfate (DS) specifically activates HCII and is abundant in the placenta, but the locations of DS and HCII in the placenta have not been determined. Dermatan Sulfate serpin family D member 1 Homo sapiens
3 Dermatan sulfate (DS) specifically activates HCII and is abundant in the placenta, but the locations of DS and HCII in the placenta have not been determined. Dermatan Sulfate serpin family D member 1 Homo sapiens
4 DS isolated from human placenta contains disaccharides implicated in activation of HCII and has anticoagulant activity similar to that of mucosal DS. Dermatan Sulfate serpin family D member 1 Homo sapiens
5 HCII colocalizes with DS in the walls of fetal blood vessels and is also present in syncytiotrophoblast cells. Dermatan Sulfate serpin family D member 1 Homo sapiens
6 Our data suggest that DS is in a position to activate HCII in the fetal blood vessels or in the stroma of placental villi after injury to the syncytiotrophoblast layer and thereby inhibit fibrin generation in the placenta. Dermatan Sulfate serpin family D member 1 Homo sapiens