Title : Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase.

Pub. Date : 2005 Oct 25

PMID : 16229464






2 Functional Relationships(s)
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1 Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase. 2-chloroacetamidine peptidyl arginine deiminase 4 Homo sapiens
2 Here, we find that 2-chloroacetamidine irreversibly inhibits both DDAH from Pseudomonas aeruginosa and human PAD4 in a time- and concentration-dependent manner, despite the nonoverlapping substrate specificities and low levels of amino acid identity of their catalytic domains. 2-chloroacetamidine peptidyl arginine deiminase 4 Homo sapiens