Title : Kinetic comparison of procaspase-3 and caspase-3.

Pub. Date : 2005 Oct 1

PMID : 16140256






2 Functional Relationships(s)
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1 Considering that those residues could be protected by caspase-3-specific inhibitor from the inactivation, the modifiers are histidine- and cysteine-specific, respectively, and the involvement of these residues in the characteristic catalytic dyad of caspases, the results indicate that the pKa values of the catalytic histidine and cysteine residues are changed during the activation process. Cysteine caspase 3 Homo sapiens
2 Considering that those residues could be protected by caspase-3-specific inhibitor from the inactivation, the modifiers are histidine- and cysteine-specific, respectively, and the involvement of these residues in the characteristic catalytic dyad of caspases, the results indicate that the pKa values of the catalytic histidine and cysteine residues are changed during the activation process. Cysteine caspase 3 Homo sapiens