Title : Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (Part 1).

Pub. Date : 2005 Sep 8

PMID : 16134950






1 Functional Relationships(s)
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1 A series of novel benzothiepines (3R,3R"-2,3,4,5-tetrahydro-5-aryl-1-benzothiepin-4-ol 1,1-dioxides) were synthesized and tested for their ability to inhibit the apical sodium dependent bile acid transport (ASBT)-mediated uptake of [(14)C]taurocholate (TC) in H14 cells. 3r,3r"-2,3,4,5-tetrahydro-5-aryl-1-benzothiepin-4-ol solute carrier family 10 member 2 Homo sapiens