Title : Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis.

Pub. Date : 2005 Sep 9

PMID : 16036217






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis. Doxorubicin cyclin dependent kinase 1 Homo sapiens
2 In this study, we investigated the role of Cdc2 and Cdk2 kinase in the regulation of the two modes of cell death induced by doxorubicin. Doxorubicin cyclin dependent kinase 1 Homo sapiens
3 During HD doxorubicin-induced apoptosis, the histone H1-associated activities of Cdc2 and Cdk2 both progressively declined in parallel with reductions in cyclin A and cyclin B protein levels. Doxorubicin cyclin dependent kinase 1 Homo sapiens
4 In contrast, during LD doxorubicin-induced cell death through mitotic catastrophe, the Cdc2 and Cdk2 kinases were transiently activated 1 day post-treatment, with similar changes seen in the protein levels of cyclin A, cyclin B, and Cdc2. Doxorubicin cyclin dependent kinase 1 Homo sapiens
5 In contrast, during LD doxorubicin-induced cell death through mitotic catastrophe, the Cdc2 and Cdk2 kinases were transiently activated 1 day post-treatment, with similar changes seen in the protein levels of cyclin A, cyclin B, and Cdc2. Doxorubicin cyclin dependent kinase 1 Homo sapiens
6 Our results demonstrate that differential regulation of Cdc2 and Cdk2 activity by different doses of doxorubicin may contribute to the induction of two distinct modes of cell death in hepatoma cells, either apoptosis or cell death through mitotic catastrophe. Doxorubicin cyclin dependent kinase 1 Homo sapiens