Title : Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity.

Pub. Date : 2005 Jul 19

PMID : 16009788






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus
2 In a mouse model of ischemic cardiomyopathy induced by repetitive ischemia/reperfusion (I/R), we postulated that downregulation of PPARalpha is regulated by reactive oxygen species and is necessary for maintaining contractile function in the heart. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus