Title : Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality.

Pub. Date : 2005 Aug 1

PMID : 15963344






2 Functional Relationships(s)
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1 MMAs(V) significantly enhanced cellular caspase 3 activity in the cellular GSH-depleted cells, and a caspase 3 inhibitor blocked MMAs(V)-induced apoptosis. Glutathione caspase 3 Homo sapiens
2 MMAs(V) also enhanced the production of cellular reactive oxygen species (ROS) in the cellular GSH-depleted cells, and addition of a membrane-permeable radical trapping reagent completely prevented both MMAs(V)-induced cellular caspase 3 activation and cytolethality in these cells. Glutathione caspase 3 Homo sapiens