Title : Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.

Pub. Date : 2005 Feb

PMID : 15673733






1 Functional Relationships(s)
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1 The bioavailability of L-3"-Fd4C administered with sodium bicarbonate was not significantly different from the bioavailability when the oral dose was administered in the absence of buffer (P = 0.49), suggesting that further development of this compound may warrant other approaches, such as development of a prodrug to improve its oral absorption. Sodium Bicarbonate immunoglobulin kappa variable 2-14 (pseudogene) Homo sapiens