Title : PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia.

Pub. Date : 2005 Jun

PMID : 15665064






2 Functional Relationships(s)
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1 Although PPAR-alpha-null mice also had elevated plasma free fatty acids, they had neither decreased cardiac GLUT-4 levels nor decreased glucose uptake during ischemia and, consequently, did not have poor recovery during reperfusion. Fatty Acids, Nonesterified peroxisome proliferator activated receptor alpha Mus musculus
2 We conclude that elevated plasma free fatty acids are associated with increased injury during ischemia due to decreased cardiac glucose uptake resulting from lower cardiac GLUT-4 protein levels, the levels of GLUT-4 being regulated, probably indirectly, through PPAR-alpha activation. Fatty Acids, Nonesterified peroxisome proliferator activated receptor alpha Mus musculus