Title : Competition of electrons to enter the respiratory chain: a new regulatory mechanism of oxidative metabolism in Saccharomyces cerevisiae.

Pub. Date : 2005 Feb 4

PMID : 15557339






2 Functional Relationships(s)
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1 In the yeast Saccharomyces cerevisiae, the most important systems for conveying excess cytosolic NADH to the mitochondrial respiratory chain are the external NADH dehydrogenases (Nde1p and Nde2p) and the glycerol-3-phosphate dehydrogenase shuttle. NAD glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C
2 Using single deletion mutants of Nde1p or Nde2p, we have shown that glycerol 3-phosphate oxidation via Gut2p is inhibited fully when NADH is oxidized via Nde1p, whereas only 50% of glycerol 3-phosphate oxidation is inhibited when Nde2p is functioning. NAD glycerol-3-phosphate dehydrogenase Saccharomyces cerevisiae S288C