Title : Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.

Pub. Date : 2005 Jan 2

PMID : 15533836






3 Functional Relationships(s)
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Protein Name
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1 Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2. spiroiminodihydantoin nei like DNA glycosylase 1 Homo sapiens
2 Herein we report that two recently identified mammalian glycosylases, NEIL1 and NEIL2, showed a high affinity for recognition and cleavage of DNA containing Gh/Ia and Sp lesions. spiroiminodihydantoin nei like DNA glycosylase 1 Homo sapiens
3 NEIL1 was able to excise the Sp lesion opposite the four natural bases in double-stranded DNA, however, NEIL2 showed little cleavage activity against the Sp lesion in duplex DNA although DNA trapping studies show recognition and binding of NEIL2 to this lesion. spiroiminodihydantoin nei like DNA glycosylase 1 Homo sapiens