Title : Fibulin-5 is a novel binding protein for extracellular superoxide dismutase.

Pub. Date : 2004 Nov 26

PMID : 15528465






7 Functional Relationships(s)
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1 The extracellular superoxide dismutase (ecSOD) plays an important role in atherosclerosis and endothelial function by modulating levels of the superoxide anion (O2*-) in the extracellular space. Superoxides superoxide dismutase 3, extracellular Mus musculus
2 The extracellular superoxide dismutase (ecSOD) plays an important role in atherosclerosis and endothelial function by modulating levels of the superoxide anion (O2*-) in the extracellular space. Superoxides superoxide dismutase 3, extracellular Mus musculus
3 The extracellular superoxide dismutase (ecSOD) plays an important role in atherosclerosis and endothelial function by modulating levels of the superoxide anion (O2*-) in the extracellular space. Superoxides superoxide dismutase 3, extracellular Mus musculus
4 The extracellular superoxide dismutase (ecSOD) plays an important role in atherosclerosis and endothelial function by modulating levels of the superoxide anion (O2*-) in the extracellular space. Superoxides superoxide dismutase 3, extracellular Mus musculus
5 Importantly, the decrease in tissue-bound ecSOD levels in aortas from fibulin-5-/- mice was associated with an increase in vascular O2*- levels. Superoxides superoxide dismutase 3, extracellular Mus musculus
6 In summary, we provide in this study the first evidence that the ecSOD-fibulin-5 interaction is required for ecSOD binding to vascular tissues, thereby regulating vascular O2*- levels. Superoxides superoxide dismutase 3, extracellular Mus musculus
7 In summary, we provide in this study the first evidence that the ecSOD-fibulin-5 interaction is required for ecSOD binding to vascular tissues, thereby regulating vascular O2*- levels. Superoxides superoxide dismutase 3, extracellular Mus musculus