Title : Clinical evaluation of interferon-gamma treatment to chronic granulomatous disease patients with splice site mutations.

Pub. Date : 2004 Oct

PMID : 15507763






2 Functional Relationships(s)
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1 IFN-gamma dependent increase of superoxide production by neutrophils was observed in three patients with Chronic Granulomatous disease from one family. Superoxides interferon gamma Homo sapiens
2 The changes of splicing pattern in the transcripts and prolonged effect on superoxide generating ability of patients" neutrophils indicate that IFN-gamma induced an ability to correct abnormal splicing of CYBB gene transcripts in progenitor cells at least in part. Superoxides interferon gamma Homo sapiens