Title : Molecular models of cyclin-dependent kinase 1 complexed with inhibitors.

Pub. Date : 2004 Nov 12

PMID : 15474478






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2). alvocidib cyclin dependent kinase 1 Homo sapiens
2 Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2). alvocidib cyclin dependent kinase 1 Homo sapiens
3 The present work describes two molecular models for the binary complexes CDK1:roscovitine and CDK1:flavopiridol. alvocidib cyclin dependent kinase 1 Homo sapiens
4 The present work describes two molecular models for the binary complexes CDK1:roscovitine and CDK1:flavopiridol. alvocidib cyclin dependent kinase 1 Homo sapiens
5 These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine. alvocidib cyclin dependent kinase 1 Homo sapiens
6 These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine. alvocidib cyclin dependent kinase 1 Homo sapiens