Title : Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.

Pub. Date : 2004 Sep 1

PMID : 15339967






4 Functional Relationships(s)
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1 RESULTS: In neuroblastoma cells, ROS generation and apoptosis were associated with fenretinide-induced increased levels of ceramide, glucosylceramide synthase activity, GD3 synthase activity, and GD3. Fenretinide GRDX Homo sapiens
2 RESULTS: In neuroblastoma cells, ROS generation and apoptosis were associated with fenretinide-induced increased levels of ceramide, glucosylceramide synthase activity, GD3 synthase activity, and GD3. Fenretinide GRDX Homo sapiens
3 Fenretinide also induced increased levels of GD2, a ganglioside derived from GD3. Fenretinide GRDX Homo sapiens
4 CONCLUSIONS: A novel pathway of fenretinide-induced apoptosis is mediated by acidic sphingomyelinase, glucosylceramide synthase, and GD3 synthase, which may represent targets for future drug development. Fenretinide GRDX Homo sapiens