Title : [Effect of XK469 and adriamycin on the growth of H460 cells in vitro and its mechanism].

Pub. Date : 2004 Jul

PMID : 15257900






3 Functional Relationships(s)
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1 Western blotting was adopted for detecting the expression of cdc2 and phos-cdc2 induced by XK469 and adriamycin. Doxorubicin cyclin dependent kinase 1 Homo sapiens
2 Western blotting was adopted for detecting the expression of cdc2 and phos-cdc2 induced by XK469 and adriamycin. Doxorubicin cyclin dependent kinase 1 Homo sapiens
3 RESULTS: Different concentrations of XK469 and adriamycin could significantly inhibit the growth of H460 cells, induce their G2/M phase arrest, and increase phos-cdc2 expression; XN472 had a lesser effect on the growth of H460 cells. Doxorubicin cyclin dependent kinase 1 Homo sapiens