Pub. Date : 2004 Aug 1
PMID : 15242824
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aminoglutethimide and 4-hydroxyandrostenedione inhibited EDDP formation by 88 and 70%, respectively, suggesting that CYP19/aromatase is the enzyme catalyzing the reaction. | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 2 | The apparent K(m) and V(max) values for the CYP19 catalyzed metabolism of methadone to EDDP were 424 +/- 92 microM and 420 +/- 89 pmol(mgprotein)(-1)min(-1), respectively. | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 3 | Kinetic analysis of a cDNA-expressed CYP19 for the metabolism of methadone to EDDP was identical to that by placental microsomes. | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 4 | Taken together, these data indicate that CYP19/aromatase is the major enzyme responsible for the metabolism of methadone to EDDP in term human placentas obtained from healthy pregnancies. | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |