Pub. Date : 2004 Sep 1
PMID : 15229189
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 2 | Human SCO1 and SCO2 are paralogous genes that code for metallochaperone proteins with essential, but poorly understood, roles in copper delivery to cytochrome c oxidase (COX). | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 3 | To investigate the molecular function of the SCO proteins, we characterized the mitochondrial copper delivery pathway in SCO1 and SCO2 patient backgrounds. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |
| 4 | We propose a model in which COX17 delivers copper to SCO2, which in turn transfers it directly to the CuA site at an early stage of COX assembly in a reaction that is facilitated by SCO1. | Copper | synthesis of cytochrome C oxidase 1 | Homo sapiens |