Title : Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol.

Pub. Date : 2004 Jun 15

PMID : 15217973






2 Functional Relationships(s)
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1 Flavopiridol is the first potent inhibitor of cyclin-dependent kinases (cdks) to reach clinical trial. alvocidib cyclin dependent kinase 1 Homo sapiens
2 Inhibition of cyclin B-cdk1 by flavopiridol accelerates exit from an abnormal mitosis associated with taxane-induced cell death and reduces the phosphorylation of survivin, preventing its stabilization and the cellular protection it affords after taxane exposure. alvocidib cyclin dependent kinase 1 Homo sapiens