Title : Heparin cofactor II is more sensitive than antithrombin to secretory impairment arising from mutations introduced into its carboxy-terminal region.

Pub. Date : 2004

PMID : 15115672






1 Functional Relationships(s)
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1 RESULTS AND CONCLUSIONS: The F450L, P455L, P477L, P477*, and T446* (*=stop codon) mutations reduced HCII secretion 6.6- to 24-fold, while the F402L, A404T, and P407L mutations reduced AT secretion in COS-1 cells 1.7- to 5.2-fold. carbonyl sulfide serpin family D member 1 Homo sapiens