Pub. Date : 1992 Sep 1
PMID : 1511437
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC). | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |
| 2 | Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC). | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |
| 3 | Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC). | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |
| 4 | Methylglyoxal bis(guanylhydrazone) (MGBG) has been studied clinically as an antitumor and antileukemic agent and is recognized as a potent but nonspecific inhibitor of the key polyamine biosynthetic enzyme, S-adenosylmethionine decarboxylase (SAMDC). | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |
| 5 | A series of four SAMDC inhibitors with structural features similar to MGBG have been found to have improved potency and specificity toward the target enzyme, SAMDC. | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |
| 6 | A series of four SAMDC inhibitors with structural features similar to MGBG have been found to have improved potency and specificity toward the target enzyme, SAMDC. | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |
| 7 | Relative to MGBG, the new derivatives were much more effective in inhibiting partially purified preparations of SAMDC (50% inhibitory concentration, 10 to 100 nM), much less effective at inhibiting diamine oxidase, and inactive toward ornithine decarboxylase. | Mitoguazone | adenosylmethionine decarboxylase 1 | Homo sapiens |