Title : Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.

Pub. Date : 2004 Aug

PMID : 15107293






2 Functional Relationships(s)
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1 Expression of AC2 and AC5/6 protein levels transiently decreased after 1 h of cicaprost exposure. cicaprost adenylate cyclase 6 Rattus norvegicus
2 Our data suggest that heterologous G(s)alpha desensitization by cicaprost is mediated predominantly by a PKA-inhibitable isoform of AC, most likely AC5/6. cicaprost adenylate cyclase 6 Rattus norvegicus