Pub. Date : 2004 May
PMID : 15051625
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Effects of Trolox on the activity and gene expression of cytochrome P450 in hepatic ischemia/reperfusion. | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus | ||
2 | The aim of this study was to investigate the effect of Trolox on hepatic microsomal cytochrome P450 (CYP) activity and gene expression during ischemia and reperfusion (I/R). | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus | ||
3 | The aim of this study was to investigate the effect of Trolox on hepatic microsomal cytochrome P450 (CYP) activity and gene expression during ischemia and reperfusion (I/R). | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus | ||
4 | Both total hepatic CYP content and NADPH-cytochrome P450 reductase activity decreased after I/R, which were restored by Trolox. | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus | ||
5 | Trolox ameliorates hepatic drug-metabolizing dysfunction, as indicated by abnormalities in CYP isoforms during I/R, and this protection is likely due to the scavenging of reactive oxygen species. | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |