Title : Effects of Trolox on the activity and gene expression of cytochrome P450 in hepatic ischemia/reperfusion.

Pub. Date : 2004 May

PMID : 15051625






5 Functional Relationships(s)
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1 Effects of Trolox on the activity and gene expression of cytochrome P450 in hepatic ischemia/reperfusion. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 The aim of this study was to investigate the effect of Trolox on hepatic microsomal cytochrome P450 (CYP) activity and gene expression during ischemia and reperfusion (I/R). 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
3 The aim of this study was to investigate the effect of Trolox on hepatic microsomal cytochrome P450 (CYP) activity and gene expression during ischemia and reperfusion (I/R). 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
4 Both total hepatic CYP content and NADPH-cytochrome P450 reductase activity decreased after I/R, which were restored by Trolox. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
5 Trolox ameliorates hepatic drug-metabolizing dysfunction, as indicated by abnormalities in CYP isoforms during I/R, and this protection is likely due to the scavenging of reactive oxygen species. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus