Title : A computational model for the electrostatic sequestration of PI(4,5)P2 by membrane-adsorbed basic peptides.

Pub. Date : 2004 Apr

PMID : 15041641






1 Functional Relationships(s)
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1 In agreement with experiments, we find that the electrostatic free energy becomes more favorable when: 1), Lys-13 and FA-MARCKS(151-175) sequester several PI(4,5)P2; 2), the linear charge density of the basic peptide increases; 3), the mol percent monovalent acidic lipid in the membrane decreases; and 4), the ionic strength of the solution decreases. (4,5)p2 myristoylated alanine rich protein kinase C substrate Homo sapiens