Title : Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques.

Pub. Date : 2004 Apr 30

PMID : 14978032






1 Functional Relationships(s)
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1 Competition studies with glycine and l-histidine indicate that copper binds to Abeta-(1-28) at pH 7.4 with an affinity of K(a) approximately 10(7) m(-1). Glycine amyloid beta precursor protein Homo sapiens