Title : Serum from dogs Infected with Babesia gibsoni inhibits maturation of reticulocytes and erythrocyte 5'-nucleotidase activity in vitro.

Pub. Date : 2003 Dec

PMID : 14709814






3 Functional Relationships(s)
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1 In the present study, in vitro incubation of canine erythrocytes demonstrated that significant inhibition of 5"-nucleotidase activity occurred in the presence of serum from dogs infected with Babesia gibsoni, when the enzyme was assayed with cytidine 5"-monophosphate (5"-CMP) and inosine 5"-monophosphate (5"-IMP) as substrates. Inosine Monophosphate 5'-nucleotidase ecto Canis lupus familiaris
2 In the present study, in vitro incubation of canine erythrocytes demonstrated that significant inhibition of 5"-nucleotidase activity occurred in the presence of serum from dogs infected with Babesia gibsoni, when the enzyme was assayed with cytidine 5"-monophosphate (5"-CMP) and inosine 5"-monophosphate (5"-IMP) as substrates. Inosine Monophosphate 5'-nucleotidase ecto Canis lupus familiaris
3 These results suggested that nucleotides such as 5"-CMP and 5"-IMP might accumulate in young erythrocytes and/or serum in dogs infected with B. gibsoni as a result of decreased activity of erythrocyte 5"-nucleotidase, resulting in the delayed maturation of reticulocytes. Inosine Monophosphate 5'-nucleotidase ecto Canis lupus familiaris