Title : The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes.

Pub. Date : 2004 Mar 19

PMID : 14699104






5 Functional Relationships(s)
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1 The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes. Guanosine Triphosphate RAB11A, member RAS oncogene family Homo sapiens
2 The small GTP-binding protein Rab11 is an essential regulator of the dynamics of recycling endosomes. Guanosine Triphosphate RAB11A, member RAS oncogene family Homo sapiens
3 Here we report the crystallographic analysis of the GDP/GTP cycle of human Rab11a, and a structure-based mutagenesis study that identifies a novel mutant phenotype. Guanosine Triphosphate RAB11A, member RAS oncogene family Homo sapiens
4 In Rab11-GDP, they contribute to a close packed symmetrical dimer, which may associate to membranes in the cell and allow Rab11 to undergo GDP/GTP cycles without recycling to the cytosol. Guanosine Triphosphate RAB11A, member RAS oncogene family Homo sapiens
5 In Rab11-GDP, they contribute to a close packed symmetrical dimer, which may associate to membranes in the cell and allow Rab11 to undergo GDP/GTP cycles without recycling to the cytosol. Guanosine Triphosphate RAB11A, member RAS oncogene family Homo sapiens