Title : Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor.

Pub. Date : 2004 Jan

PMID : 14684580






2 Functional Relationships(s)
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1 In 10 healthy male volunteers, ASBT protein expression was increased 1.34 (0.11)-fold (mean (SEM); p<0.05) after 21 days" intake of budesonide (9 mg/day) whereas expression of the peptide transporter 1 was unaffected. Budesonide solute carrier family 10 member 2 Homo sapiens
2 Reporter constructs of the human ASBT promoter were activated 15-20-fold by coexpression of the glucocorticoid receptor (GR) and exposure to the GR ligands dexamethasone or budesonide. Budesonide solute carrier family 10 member 2 Homo sapiens