Title : Activation of brain prostanoid EP3 receptors via arachidonic acid cascade during behavioral suppression induced by Delta8-tetrahydrocannabinol.

Pub. Date : 2004 Jan

PMID : 14675158






2 Functional Relationships(s)
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1 In the present study, we investigated the participation of the prostanoid EP3 receptor, the target of PGE2 in the brain, in behavioral suppression induced by Delta8-tetrahydrocannabinol (Delta8-THC), an isomer of the naturally occurring Delta9-THC, using a one-lever operant task in rats. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus
2 It is concluded that the suppression of lever-pressing behavior by cannabinoid is due to activation of the prostanoid EP3 receptor through an elevation of PGE2 in the brain. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus