Title : A novel class of apical sodium co-dependent bile acid transporter inhibitors: the 1,2-benzothiazepines.

Pub. Date : 2003 Nov 3

PMID : 14552767






2 Functional Relationships(s)
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1 A series of 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol 1,1-dioxides were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT) for the potential treatment for hyperlipidemia. 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol solute carrier family 10 member 2 Homo sapiens
2 A series of 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol 1,1-dioxides were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT) for the potential treatment for hyperlipidemia. 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol solute carrier family 10 member 2 Homo sapiens