Pub. Date : 2004 Jan 2
PMID : 14532297
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid. | Tretinoin | cytochrome P450 family 26 subfamily C member 1 | Homo sapiens |
| 2 | Transiently transfected cells expressing CYP26C1 convert atRA to polar water-soluble metabolites similar to those generated by CYP26A1 and -B1. | Tretinoin | cytochrome P450 family 26 subfamily C member 1 | Homo sapiens |
| 3 | Competition studies with all-trans, 13-cis, and 9-cis isomers of retinoic acid demonstrated that atRA was the preferred substrate for CYP26C1. | Tretinoin | cytochrome P450 family 26 subfamily C member 1 | Homo sapiens |
| 4 | Competition studies with all-trans, 13-cis, and 9-cis isomers of retinoic acid demonstrated that atRA was the preferred substrate for CYP26C1. | Tretinoin | cytochrome P450 family 26 subfamily C member 1 | Homo sapiens |
| 5 | Specifically, CYP26C1 can also recognize and metabolize 9-cis-RA and is much less sensitive than the other CYP26 family members to the inhibitory effects of ketoconazole. | Tretinoin | cytochrome P450 family 26 subfamily C member 1 | Homo sapiens |