Title : Glucocorticoid metabolism and reproduction: a tale of two enzymes.

Pub. Date : 2003 Oct

PMID : 14525525






1 Functional Relationships(s)
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1 To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity NAD(+)-dependent enzyme that catalyses the enzymatic inactivation of glucocorticoids. NAD hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens