Title : A defect in the p53 response pathway induced by de novo purine synthesis inhibition.

Pub. Date : 2003 Dec 5

PMID : 14517211






1 Functional Relationships(s)
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1 We now report that the p53-dependent G1 checkpoint is blocked in human carcinoma cell lines after inhibition of de novo purine synthesis by folate analogs inhibitory to glycinamide ribonucleotide formyltransferase (GART). Folic Acid tumor protein p53 Homo sapiens