Title : Effect of adenylate cyclase activators on C5a-induced human neutrophil aggregation, enzyme release and superoxide production.

Pub. Date : 1992

PMID : 1375201






3 Functional Relationships(s)
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1 Effect of adenylate cyclase activators on C5a-induced human neutrophil aggregation, enzyme release and superoxide production. Superoxides complement C5a receptor 1 Homo sapiens
2 C5a-stimulated superoxide production was markedly inhibited by adenylate cyclase activators, and the order of potency was PGE1 greater than isoproterenol greater than epinephrine greater than PGF2 alpha, which correlated with intracellular cAMP levels. Superoxides complement C5a receptor 1 Homo sapiens
3 These results suggest that in the human neutrophil: (1) C5a-induced superoxide production is more sensitive to regulation by cAMP than neutrophil aggregation or enzyme release, and (2) the type of receptor occupied as well as the threshold level of cAMP are important in the regulation of neutrophil aggregation and enzyme release stimulated by C5a. Superoxides complement C5a receptor 1 Homo sapiens