Title : Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways.

Pub. Date : 1992 Jul

PMID : 1322051






5 Functional Relationships(s)
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1 Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways. Superoxides complement C5a receptor 1 Homo sapiens
2 In the current studies rat pulmonary artery endothelial cells (RPAEC) responded to human recombinant C5a and tumor necrosis factor-alpha (TNF-alpha) with the generation of superoxide (O2-). Superoxides complement C5a receptor 1 Homo sapiens
3 In the current studies rat pulmonary artery endothelial cells (RPAEC) responded to human recombinant C5a and tumor necrosis factor-alpha (TNF-alpha) with the generation of superoxide (O2-). Superoxides complement C5a receptor 1 Homo sapiens
4 RPAEC responded to C5a and TNF-alpha in a dose-dependent manner, with increases in intracellular Ca2+ (Cai2+), formation of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3], and generation of O2-. Superoxides complement C5a receptor 1 Homo sapiens
5 Pertussis toxin pretreatment abolished the ability of C5a to cause increases in Ins(1,4,5)P3 and Cai2+ and formation of O2- but did not inhibit the changes in Cai2+ and formation of O2- after addition of TNF-alpha. Superoxides complement C5a receptor 1 Homo sapiens