Title : Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice.

Pub. Date : 2003 Oct 3

PMID : 12933702






5 Functional Relationships(s)
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Protein Name
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1 The relevance of extracellular superoxide dismutase (ecSOD) for the detoxification of vascular O2.- is unknown. Superoxides superoxide dismutase 3, extracellular Mus musculus
2 The relevance of extracellular superoxide dismutase (ecSOD) for the detoxification of vascular O2.- is unknown. Superoxides superoxide dismutase 3, extracellular Mus musculus
3 Vascular O2.-, as measured by lucigenin chemiluminescence, was higher in ecSOD-/- compared with ecSOD+/+ mice and was increased by clipping. Superoxides superoxide dismutase 3, extracellular Mus musculus
4 Vascular O2.-, as measured by lucigenin chemiluminescence, was higher in ecSOD-/- compared with ecSOD+/+ mice and was increased by clipping. Superoxides superoxide dismutase 3, extracellular Mus musculus
5 These data reveal that endogenous ecSOD is a major antagonistic principle to vascular O2.-, controlling blood pressure and vascular function in angiotensin II-dependent models of hypertension. Superoxides superoxide dismutase 3, extracellular Mus musculus