Title : Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.

Pub. Date : 2003 Aug 14

PMID : 12904077






1 Functional Relationships(s)
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1 It has been shown by extensive studies that alpha-MSH bioactivity is critically dependent on the core or central tetrapeptide sequence, His-Phe-Arg-Trp, however with poor selectivity for the human MC3R-MC5R. Arginine proopiomelanocortin Homo sapiens