Title : Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates.

Pub. Date : 2003 Aug 22

PMID : 12901862






2 Functional Relationships(s)
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1 The sulfhydryl protecting reagent dithiothreitol blocked thiram-induced inhibition and NAD+ partially protected 11 beta-HSD2 activity, indicating that DTCs act at the cofactor-binding site. NAD hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
2 A 3D-model of 11 beta-HSD2 identified Cys90 in the NAD(+)-binding site as a likely target of DTCs, which was supported by a 99% reduced activity of mutant Cys90 to serine. NAD hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens