Pub. Date : 2003 Jul 18
PMID : 12880976
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | The stress-induced transcription factor GADD153 and the Bcl2-related protein Bak are upregulated in response to fenretinide. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Neither GADD153 or Bak were induced by chemotherapeutic agents but over expression of GADD153 results in increased sensitivity to fenretinide-induced apoptosis. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Therefore, fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterised by the reactive oxygen species-dependent induction of GADD153 and Bak. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |