Title : Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma.

Pub. Date : 2003 Jul 18

PMID : 12880976






4 Functional Relationships(s)
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1 Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma. Fenretinide DNA damage inducible transcript 3 Homo sapiens
2 The stress-induced transcription factor GADD153 and the Bcl2-related protein Bak are upregulated in response to fenretinide. Fenretinide DNA damage inducible transcript 3 Homo sapiens
3 Neither GADD153 or Bak were induced by chemotherapeutic agents but over expression of GADD153 results in increased sensitivity to fenretinide-induced apoptosis. Fenretinide DNA damage inducible transcript 3 Homo sapiens
4 Therefore, fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterised by the reactive oxygen species-dependent induction of GADD153 and Bak. Fenretinide DNA damage inducible transcript 3 Homo sapiens