Title : Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats.

Pub. Date : 2003 Jul 9

PMID : 12853415






2 Functional Relationships(s)
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1 Perfusion of either PGE2 or the EP4 agonist into the TMN at a dose of 200 pmol/min for 1 hr increased histidine decarboxylase activity, histidine decarboxylase mRNA level, and histamine content in the hypothalamus. Dinoprostone histidine decarboxylase Rattus norvegicus
2 Perfusion of either PGE2 or the EP4 agonist into the TMN at a dose of 200 pmol/min for 1 hr increased histidine decarboxylase activity, histidine decarboxylase mRNA level, and histamine content in the hypothalamus. Dinoprostone histidine decarboxylase Rattus norvegicus