Pub. Date : 2003 Sep
PMID : 12829805
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of human and murine HSD17B7 in an Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium. | Sterols | hydroxysteroid (17-beta) dehydrogenase 7 | Mus musculus |
| 2 | Expression of human and murine HSD17B7 in an Erg27p-deficient yeast strain complements the 3-ketosteroid reductase deficiency of the cells and restores growth on sterol-deficient medium. | Sterols | hydroxysteroid (17-beta) dehydrogenase 7 | Mus musculus |
| 3 | Further critical evidence for a role of HSD17B7 in cholesterol metabolism is provided by the observation that its murine ortholog is a member of the same highly distinct embryonic synexpression group as hydroxymethyl-glutaryl-coenzyme A reductase, the rate-limiting enzyme of sterol biogenesis, and is specifically expressed in tissues that are involved in the pathogenesis of congenital cholesterol-deficiency disorders. | Sterols | hydroxysteroid (17-beta) dehydrogenase 7 | Mus musculus |