Title : Interaction between alcohol and nitric oxide on ACTH release in the rat.

Pub. Date : 2003 Jun

PMID : 12824821






9 Functional Relationships(s)
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1 Interaction between alcohol and nitric oxide on ACTH release in the rat. Alcohols proopiomelanocortin Homo sapiens
2 BACKGROUND: This work was designed to determine whether alcohol increased nitric oxide (NO) levels within the hypothalamic-pituitary (HP) axis, whether endogenous NO participated in the known ability of alcohol to release ACTH and, conversely, whether prior alcohol treatment altered the ACTH response to NO. Alcohols proopiomelanocortin Homo sapiens
3 BACKGROUND: This work was designed to determine whether alcohol increased nitric oxide (NO) levels within the hypothalamic-pituitary (HP) axis, whether endogenous NO participated in the known ability of alcohol to release ACTH and, conversely, whether prior alcohol treatment altered the ACTH response to NO. Alcohols proopiomelanocortin Homo sapiens
4 The role of endogenous NO then was studied by blocking the activity of NO synthase, the enzyme responsible for formation of this gas, and determining whether this treatment altered the ACTH response to alcohol. Alcohols proopiomelanocortin Homo sapiens
5 Finally, we investigated the influence of alcohol on the ACTH response to NO. Alcohols proopiomelanocortin Homo sapiens
6 The ACTH response to acute intragastric alcohol injection was significantly (p < 0.01) decreased by the arginine derivative N omega-nitro-L-arginine-methylester, which nonspecifically blocks NOS activity, as well as by the specific neuronal NOS antagonist 7-nitroindazole. Alcohols proopiomelanocortin Homo sapiens
7 A 5 but not 1 or 3 day exposure to intermittent alcohol vapors interfered with the ACTH response to the intracerebroventricular injection of the NO donor 3-morpholino-sydnonimine. Alcohols proopiomelanocortin Homo sapiens
8 CONCLUSION: Acute alcohol injection increases NO levels in blood and the HP axis, and these responses seem to facilitate the ACTH response to alcohol. Alcohols proopiomelanocortin Homo sapiens
9 CONCLUSION: Acute alcohol injection increases NO levels in blood and the HP axis, and these responses seem to facilitate the ACTH response to alcohol. Alcohols proopiomelanocortin Homo sapiens